カルノソール

カルノソール
識別情報
CAS登録番号	5957-80-2
PubChem	442009
ChemSpider	390568
	SMILES CC(C)C1=CC2=C(C(=C1O)O)[C@@]34CCCC([C@@H]3C[C@@H]2OC4=O)(C)C;
	InChI InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1 Key: XUSYGBPHQBWGAD-PJSUUKDQSA-N; InChI=1/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1 Key: XUSYGBPHQBWGAD-PJSUUKDQBN;
特性
化学式	C20H26O4
モル質量	330.42 g/mol
精密質量	330.1831084 u
	特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。

カルノソール(Carnosol)は、ローズマリー(Rosmarinus officinalis)^[1]やサルビア・パキフィラ(Salvia pachyphylla)^[2]等のハーブに含まれるフェノール性化合物である。カルノソールはカルノシン酸と同様にNrf2（NFE2L2）を活性化し、生体防御機構を作動させ、神経細胞死を抑制することが知られている^[3]。

出典

^ Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages. Ai-Hsiang Lo, Yu-Chih Liang, Shoei-Yn Lin-Shiau, Chi-Tang Ho and Jen-Kun Lin, Carcinogenesis, 2002, 23 (6), pages 983-991, doi:10.1093/carcin/23.6.983
^ Ivan C. Guerrero, Lucia S. Andres, Leticia G. Leon, Ruben P. Machin, Jose M. Padron, Javier G. Luis, and Jose Delgadillo. Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines. J. Nat. Prod. (2006) 69, 1803-1805
^ Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners.Satoh T, Izumi M, Inukai Y, Tsutsumi Y, Nakayama N, Kosaka K, Shimojo Y, Kitajima C, Itoh K, Yokoi T, Shirasawa T. Neurosci Lett. 2008 Apr 4;434(3):260-5. doi: 10.1016/j.neulet.2008.01.079. Epub 2008 Feb 13. PMID 18329808.

[1] Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages. Ai-Hsiang Lo, Yu-Chih Liang, Shoei-Yn Lin-Shiau, Chi-Tang Ho and Jen-Kun Lin, Carcinogenesis, 2002, 23 (6), pages 983-991, doi:10.1093/carcin/23.6.983

[2] Ivan C. Guerrero, Lucia S. Andres, Leticia G. Leon, Ruben P. Machin, Jose M. Padron, Javier G. Luis, and Jose Delgadillo. Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines. J. Nat. Prod. (2006) 69, 1803-1805

[3] Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners.Satoh T, Izumi M, Inukai Y, Tsutsumi Y, Nakayama N, Kosaka K, Shimojo Y, Kitajima C, Itoh K, Yokoi T, Shirasawa T. Neurosci Lett. 2008 Apr 4;434(3):260-5. doi: 10.1016/j.neulet.2008.01.079. Epub 2008 Feb 13. PMID 18329808.

[1]

[2]

[3]