サイクリンA1

CCNA1
識別子
記号	CCNA1, CT146, Cyclin A1
外部ID	OMIM: 604036 MGI: 108042 HomoloGene: 31203 GeneCards: CCNA1
遺伝子の位置 (ヒト)
染色体	13番染色体 (ヒト)
終点	36,442,870 bp
遺伝子の位置 (マウス)
染色体	3番染色体 (マウス)
終点	54,962,922 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• 血漿タンパク結合; • protein kinase activity; • cyclin-dependent protein serine/threonine kinase regulator activity; • プロテインキナーゼ結合;
細胞の構成要素	• microtubule cytoskeleton; • 細胞質基質; • 細胞核; • 核質; • cyclin A1-CDK2 complex; • cyclin-dependent protein kinase holoenzyme complex; • 細胞質; • cyclin A2-CDK2 complex;
生物学的プロセス	• 細胞分裂; • 細胞周期; • male meiosis I; • regulation of transcription involved in G1/S transition of mitotic cell cycle; • 精子形成; • protein deubiquitination; • regulation of cyclin-dependent protein serine/threonine kinase activity; • 体細胞分裂; • タンパク質リン酸化; • regulation of mitotic nuclear division; • positive regulation of cell population proliferation; • positive regulation of cell cycle; • mitotic cell cycle phase transition;
	出典:Amigo / QuickGO
オルソログ
	8900
	12427
	ENSG00000133101
	ENSMUSG00000027793
	P78396
	Q61456
	NM_001111045; NM_001111046; NM_001111047; NM_003914
	NM_007628; NM_001305221
	NP_001104515; NP_001104516; NP_001104517; NP_003905
	NP_001292150; NP_031654
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

→「サイクリンA」も参照

サイクリンA1（英: cyclin A1）は、ヒトではCCNA1遺伝子にコードされるタンパク質である^[5]。

機能

CCNA1遺伝子にコードされるサイクリンA1タンパク質は、高度に保存されたサイクリンファミリーに属する。このファミリーのメンバーは、細胞周期を通じてタンパク質の存在量に劇的な周期性がみられることで特徴づけられる。サイクリンはサイクリン依存性キナーゼ（CDK）の調節因子として機能する。さまざまなサイクリンはそれぞれ異なる発現と分解のパターンを示し、細胞周期のイベントの時間的調整に寄与する。サイクリンA1は精巣と脳のほか、いくつかの白血病細胞株で発現していることが示されており、主に減数分裂の制御に機能すると考えられている。このサイクリンはCDK1とCDK2の双方に結合する。S期とG₂期に異なるキナーゼ活性を示し、細胞周期の異なる機能を調節する。このサイクリンは、Rbファミリータンパク質、転写因子E2F1（英語版）、Kip/CipファミリーのCDK阻害タンパク質など、重要な細胞周期調節因子に結合することが知られている^[6]。

相互作用

サイクリンA1は次に挙げる因子と相互作用する。

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133101 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027793 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ ^a ^b “Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines”. Cancer Res. 57 (5): 913–920. (March 1997). PMID 9041194.
^ “Entrez Gene: CCNA1 cyclin A1”. 2021年6月19日閲覧。
^ “Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex”. Biochem. Biophys. Res. Commun. 268 (2): 530–534. (February 2000). doi:10.1006/bbrc.2000.2167. PMID 10679238.
^ “A distinct cyclin A is expressed in germ cells in the mouse”. Development 122 (1): 53–64. (January 1996). PMID 8565853.
^ ^a ^b “Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function”. Blood 97 (7): 2091–2097. (April 2001). doi:10.1182/blood.v97.7.2091. PMID 11264176.
^ “The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases”. Nat. Cell Biol. 1 (7): 438–443. (November 1999). doi:10.1038/15674. PMID 10559988.
^ ^a ^b “Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins”. Mol. Cell. Biol. 19 (3): 2400–2407. (March 1999). doi:10.1128/mcb.19.3.2400. PMC 84032. PMID 10022926.
^ ^a ^b “Identification of interaction partners and substrates of the cyclin A1-CDK2 complex”. J. Biol. Chem. 279 (32): 33727–33741. (August 2004). doi:10.1074/jbc.M401708200. PMID 15159402.

関連文献

“Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins”. Oncogene 11 (8): 1581–1588. (1995). PMID 7478582.
“Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation”. Mol. Cell. Biol. 14 (12): 8420–8431. (1994). doi:10.1128/MCB.14.12.8420. PMC 359381. PMID 7969176.
“Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene 138 (1–2): 171–174. (1994). doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
“G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently”. J. Biol. Chem. 268 (11): 8298–8308. (1993). PMID 8463339.
“A distinct cyclin A is expressed in germ cells in the mouse”. Development 122 (1): 53–64. (1996). PMID 8565853.
“BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases”. Oncogene 15 (2): 143–157. (1997). doi:10.1038/sj.onc.1201252. PMID 9244350.
“Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–156. (1997). doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
“Cyclin A1 is required for meiosis in the male mouse”. Nat. Genet. 20 (4): 377–380. (1998). doi:10.1038/3855. PMID 9843212.
“Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins”. Mol. Cell. Biol. 19 (3): 2400–2407. (1999). doi:10.1128/mcb.19.3.2400. PMC 84032. PMID 10022926.
“Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage”. Dev. Biol. 207 (2): 408–418. (1999). doi:10.1006/dbio.1998.9156. PMID 10068472.
“Cyclin A1 expression in leukemia and normal hematopoietic cells”. Blood 93 (6): 2067–2074. (1999). PMID 10068680.
“Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene”. J. Biol. Chem. 274 (16): 11220–11228. (1999). doi:10.1074/jbc.274.16.11220. PMID 10196209.
“BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site”. Mol. Cell. Biol. 19 (7): 4843–4854. (1999). doi:10.1128/MCB.19.7.4843. PMC 84283. PMID 10373534.
“The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases”. Nat. Cell Biol. 1 (7): 438–443. (1999). doi:10.1038/15674. PMID 10559988.
“A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice”. Dev. Biol. 224 (2): 388–400. (2000). doi:10.1006/dbio.2000.9776. PMID 10926775.
“DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788–1795. (2000). doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
“Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology”. FEBS Lett. 490 (1–2): 75–78. (2001). doi:10.1016/S0014-5793(01)02128-7. PMID 11172814.
“Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing”. EMBO Rep. 1 (3): 287–292. (2000). doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
“Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function”. Blood 97 (7): 2091–2097. (2001). doi:10.1182/blood.V97.7.2091. PMID 11264176.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133101 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027793 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid9041194-5] “Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines”. Cancer Res. 57 (5): 913–920. (March 1997). PMID 9041194.

[entrez-6] “Entrez Gene: CCNA1 cyclin A1”. 2021年6月19日閲覧。

[pmid10679238-7] “Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex”. Biochem. Biophys. Res. Commun. 268 (2): 530–534. (February 2000). doi:10.1006/bbrc.2000.2167. PMID 10679238.

[pmid8565853-8] “A distinct cyclin A is expressed in germ cells in the mouse”. Development 122 (1): 53–64. (January 1996). PMID 8565853.

[pmid11264176-9] “Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function”. Blood 97 (7): 2091–2097. (April 2001). doi:10.1182/blood.v97.7.2091. PMID 11264176.

[pmid10559988-10] “The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases”. Nat. Cell Biol. 1 (7): 438–443. (November 1999). doi:10.1038/15674. PMID 10559988.

[pmid10022926-11] “Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins”. Mol. Cell. Biol. 19 (3): 2400–2407. (March 1999). doi:10.1128/mcb.19.3.2400. PMC 84032. PMID 10022926.

[pmid15159402-12] “Identification of interaction partners and substrates of the cyclin A1-CDK2 complex”. J. Biol. Chem. 279 (32): 33727–33741. (August 2004). doi:10.1074/jbc.M401708200. PMID 15159402.

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