ホスホリパーゼA2受容体
ホスホリパーゼA2受容体（ホスホリパーゼA2じゅようたい）とは、PLA2R1 遺伝子によってコードされている受容体タンパク質である[1][2]。ホスホリパーゼA2は、リン脂質から脂肪酸を遊離させる酵素である。一部のヘビ毒などにも含まれる。
M型ホスホリパーゼA2受容体は、特発性膜性糸球体腎炎の抗原であると示唆されている[3]。
脚注
[編集]- ^ Ancian P, Lambeau G, Mattei MG, Lazdunski M (May 1995). “The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization”. J Biol Chem 270 (15): 8963–70. doi:10.1074/jbc.270.15.8963. PMID 7721806.
- ^ Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H (Nov 1994). “Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals”. Eur J Biochem 225 (1): 375–82. doi:10.1111/j.1432-1033.1994.00375.x. PMID 7925459.
- ^ M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy — NEJM
関連文献
[編集]- Silliman CC, Moore EE, Zallen G, et al. (2002). “Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion.”. Am. J. Physiol., Cell Physiol. 283 (4): C1102–13. doi:10.1152/ajpcell.00608.2001. PMID 12225974.
- Wistow G, Bernstein SL, Wyatt MK, et al. (2002). “Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.”. Mol. Vis. 8: 196–204. PMID 12107411.
- Morioka Y, Saiga A, Yokota Y, et al. (2000). “Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor.”. Arch. Biochem. Biophys. 381 (1): 31–42. doi:10.1006/abbi.2000.1977. PMID 11019817.
- Yokota Y, Higashino K, Nakano K, et al. (2000). “Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor.”. FEBS Lett. 478 (1–2): 187–91. doi:10.1016/S0014-5793(00)01848-2. PMID 10922494.
- Yokota Y, Ikeda M, Higashino K, et al. (2000). “Enhanced tissue expression and elevated circulating level of phospholipase A(2) receptor during murine endotoxic shock”. Arch. Biochem. Biophys. 379 (1): 7–17. doi:10.1006/abbi.2000.1849. PMID 10864436.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). “Shotgun sequencing of the human transcriptome with ORF expressed sequence tags”. Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.