小タンパク質

小タンパク質（しょうたんぱくしつ、英: small proteins）は、通常は100アミノ酸未満の長さを持つ、多様なフォールドクラス（英語版）のタンパク質である^[1]^[2]^[3]。それらの三次構造は、通常、ジスルフィド架橋^[4]、金属リガンド^[5]、および/またはヘムなどの補酵素によって維持されている。小タンパク質の中には、特定の酵素と直接相互作用することで重要な制御機能を果たし、それゆえに微生物の生物工学的応用のための興味深いツールでもある^[6]。

参照項目

脚注

^ Kihara D, Skolnick J (December 2003). “The PDB is a covering set of small protein structures”. Journal of Molecular Biology 334 (4): 793–802. doi:10.1016/j.jmb.2003.10.027. PMID 14636603.
^ Su M, Ling Y, Yu J, Wu J, Xiao J (December 2013). “Small proteins: untapped area of potential biological importance”. Frontiers in Genetics 4: 286. doi:10.3389/fgene.2013.00286. PMC 3864261. PMID 24379829.
^ Storz G, Wolf YI, Ramamurthi KS (2014-06-02). “Small proteins can no longer be ignored”. Annual Review of Biochemistry 83 (1): 753–77. doi:10.1146/annurev-biochem-070611-102400. PMC 4166647. PMID 24606146.
^ Cheek S, Krishna SS, Grishin NV (May 2006). “Structural classification of small, disulfide-rich protein domains”. Journal of Molecular Biology 359 (1): 215–37. doi:10.1016/j.jmb.2006.03.017. PMID 16618491.
^ Berg JM (April 1990). “Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules”. The Journal of Biological Chemistry 265 (12): 6513–6. PMID 2108957.
^ Brandenburg F, Klähn S (2020). “Small but smart: On the diverse role of small proteins in the regulation of cyanobacterial metabolism”. Life 10 (12): 1-15. doi:10.3390/life10120322.

[1] Kihara D, Skolnick J (December 2003). “The PDB is a covering set of small protein structures”. Journal of Molecular Biology 334 (4): 793–802. doi:10.1016/j.jmb.2003.10.027. PMID 14636603.

[2] Su M, Ling Y, Yu J, Wu J, Xiao J (December 2013). “Small proteins: untapped area of potential biological importance”. Frontiers in Genetics 4: 286. doi:10.3389/fgene.2013.00286. PMC 3864261. PMID 24379829.

[3] Storz G, Wolf YI, Ramamurthi KS (2014-06-02). “Small proteins can no longer be ignored”. Annual Review of Biochemistry 83 (1): 753–77. doi:10.1146/annurev-biochem-070611-102400. PMC 4166647. PMID 24606146.

[4] Cheek S, Krishna SS, Grishin NV (May 2006). “Structural classification of small, disulfide-rich protein domains”. Journal of Molecular Biology 359 (1): 215–37. doi:10.1016/j.jmb.2006.03.017. PMID 16618491.

[:02-5] Berg JM (April 1990). “Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules”. The Journal of Biological Chemistry 265 (12): 6513–6. PMID 2108957.

[6] Brandenburg F, Klähn S (2020). “Small but smart: On the diverse role of small proteins in the regulation of cyanobacterial metabolism”. Life 10 (12): 1-15. doi:10.3390/life10120322.

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