20α-ヒドロキシステロイドデヒドロゲナーゼ
| 20α-ヒドロキシステロイドデヒドロゲナーゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.1.1.149 | ||||||||
| CAS登録番号 | 9040-08-8 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / QuickGO | ||||||||
| |||||||||
20α-ヒドロキシステロイドデヒドロゲナーゼ（20α-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。
- 17α,20α-ジヒドロキシプレグン-4-エン-3-オン + NAD(P)+ 17α-ヒドロキシプロゲステロン + NAD(P)H + H+
反応式の通り、この酵素の基質は17α,20α-ジヒドロキシプレグン-4-エン-3-オンとNAD(P)+、生成物は17α-ヒドロキシプロゲステロンとNAD(P)HとH+である。
組織名は20α-hydroxysteroid:NAD(P)+ 20-oxidoreductaseで、別名に20α-hydroxy steroid dehydrogenase, 20α-HSD, 20α-HSDHがある。
参考文献
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- Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y (March 2007). “Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone”. Endocrinology 148 (3): 976–88. doi:10.1210/en.2006-1100. PMID 17122075.