AKAP13

AKAP13
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	2DRN, 2LG1, 4D0N, 4D0O
識別子
記号	AKAP13, A kinase (PRKA) anchor protein 13, AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47, A-kinase anchoring protein 13, A-kinase anchor protein 13
外部ID	OMIM: 604686 MGI: 2676556 HomoloGene: 4903 GeneCards: AKAP13
遺伝子の位置 (ヒト)
染色体	15番染色体 (ヒト)
終点	85,749,358 bp
遺伝子の位置 (マウス)
染色体	7番染色体 (マウス)
終点	75,754,609 bp
遺伝子オントロジー
分子機能	• 金属イオン結合; • MAP-kinase scaffold activity; • guanyl-nucleotide exchange factor activity; • 血漿タンパク結合; • molecular adaptor activity; • protein kinase A binding; • シグナルトランスデューサー活性; • cAMP-dependent protein kinase activity;
細胞の構成要素	• 膜; • 細胞質基質; • actin cytoskeleton; • perinuclear region of cytoplasm; • 細胞核; • 細胞皮質; • マイクロフィラメント; • cortical actin cytoskeleton; • 細胞質; • 細胞内;
生物学的プロセス	• regulation of cardiac muscle hypertrophy; • 骨発生; • intracellular signal transduction; • regulation of glucocorticoid mediated signaling pathway; • positive regulation of Rho protein signal transduction; • regulation of sarcomere organization; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • adrenergic receptor signaling pathway; • regulation of small GTPase mediated signal transduction; • adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; • 心臓発生; • positive regulation of apoptotic process; • cardiac muscle cell differentiation; • regulation of Rho protein signal transduction; • タンパク質リン酸化; • regulation of protein kinase activity; • nuclear export; • Gタンパク質共役受容体シグナル伝達経路; • positive regulation of MAP kinase activity; • cell growth involved in cardiac muscle cell development;
	出典:Amigo / QuickGO
オルソログ
	11214
	75547
	ENSG00000170776
	ENSMUSG00000066406
	Q12802,A0A087WY36
	E9Q394
	NM_144767; NM_001270546; NM_006738; NM_007200; NM_032162
	NM_029332
	NP_001257475; NP_006729; NP_009131
	NP_083608
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

Aキナーゼアンカータンパク質13（エーキナーゼアンカータンパクしつ13、英: A-kinase anchor protein 13）は、ヒトAKAP13遺伝子にコードされているタンパク質である^[5]^[6]^[7]。

Aキナーゼアンカータンパク質 (AKAP) 類は、構造的に多様性を持ったタンパク質の一群である。プロテインキナーゼA (PKA) の調整サブユニットに結合する共通機能を有しており、ホロ酵素を細胞内の別々の場所に縛り付ける。この遺伝子はAKAPファミリーのメンバーをコードしている。この遺伝子の選択的スプライシングの結果、dblがん遺伝子相同 (dbl oncogene homology, DH) ドメインおよびプレクストリン相同ドメイン（英語版）（PHドメイン）を含む異なるアイソフォームをコードしている少なくとも3つの転写バリアントが生じる。DHドメインは低分子量GTP結合タンパク質であるRho/Racファミリーのグアニンヌクレオチド交換活性化に関与しており、不活性型GTPaseをシグナルを伝達することができる活性型に変換する。PHドメインは多面的な機能を有している。したがって、これらのアイソフォームは、Rhoシグナル経路をまとめる足場タンパク質として機能し、さらにプロテインキナーゼAアンカータンパク質としても機能する^[7]。

相互作用

AKAP13は、エストロゲン受容体α^[5]、CTNNAL1^[8]、PRKAR2A^[9]^[10]と相互作用することが示されている。

脚注

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170776 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066406 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ ^a ^b Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S, Segars J (Jul 1998). “Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action”. Oncogene 16 (19): 2513–26. doi:10.1038/sj.onc.1201783. PMID 9627117.
^ Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD (Sep 1991). “Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif”. J Biol Chem 266 (22): 14188–92. PMID 1860836.
^ ^a ^b “Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13”. 2012年1月26日閲覧。
^ Park, Brian; Nguyen Nhan T, Dutt Parmesh, Merdek Keith D, Bashar Mariam, Sterpetti Paola, Tosolini Alessandra, Testa Joseph R, Toksoz Deniz (Nov. 2002). “Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation”. J. Biol. Chem. (United States) 277 (47): 45361–70. doi:10.1074/jbc.M202447200. ISSN 0021-9258. PMID 12270917.
^ Alto, Neal M; Soderling Scott H, Hoshi Naoto, Langeberg Lorene K, Fayos Rosa, Jennings Patricia A, Scott John D (Apr. 2003). “Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring”. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (8): 4445–50. doi:10.1073/pnas.0330734100. ISSN 0027-8424. PMC 153575. PMID 12672969.
^ Carr, D W; Hausken Z E, Fraser I D, Stofko-Hahn R E, Scott J D (Jul. 1992). “Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain”. J. Biol. Chem. (UNITED STATES) 267 (19): 13376–82. ISSN 0021-9258. PMID 1618839.

推薦文献

Carr DW, Hausken ZE, Fraser ID, et al. (1992). “Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain.”. J. Biol. Chem. 267 (19): 13376–82. PMID 1618839.
Hausken ZE, Coghlan VM, Hastings CA, et al. (1994). “Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5.”. J. Biol. Chem. 269 (39): 24245–51. PMID 7929081.
Toksoz D, Williams DA (1994). “Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products.”. Oncogene 9 (2): 621–8. PMID 8290273.
Sterpetti P, Hack AA, Bashar MP, et al. (1999). “Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting.”. Mol. Cell. Biol. 19 (2): 1334–45. PMC 116062. PMID 9891067.
Sagi SA, Seasholtz TM, Kobiashvili M, et al. (2001). “Physical and functional interactions of Galphaq with Rho and its exchange factors.”. J. Biol. Chem. 276 (18): 15445–52. doi:10.1074/jbc.M008961200. PMC 1761691. PMID 11278452.
Newlon MG, Roy M, Morikis D, et al. (2001). “A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes.”. EMBO J. 20 (7): 1651–62. doi:10.1093/emboj/20.7.1651. PMC 145475. PMID 11285229.
Diviani D, Soderling J, Scott JD (2001). “AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.”. J. Biol. Chem. 276 (47): 44247–57. doi:10.1074/jbc.M106629200. PMID 11546812.
Driggers PH, Segars JH, Rubino DM (2002). “The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway.”. J. Biol. Chem. 276 (50): 46792–7. doi:10.1074/jbc.M106927200. PMID 11579095.
Klussmann E, Edemir B, Pepperle B, et al. (2001). “Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.”. FEBS Lett. 507 (3): 264–8. doi:10.1016/S0014-5793(01)02995-7. PMID 11696353.
Park B, Nguyen NT, Dutt P, et al. (2003). “Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation.”. J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917.
Tan YC, Wu H, Wang WN, et al. (2003). “Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors.”. Anal. Biochem. 310 (2): 156–62. doi:10.1016/S0003-2697(02)00382-2. PMID 12423633.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Spierings E, Brickner AG, Caldwell JA, et al. (2003). “The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein.”. Blood 102 (2): 621–9. doi:10.1182/blood-2003-01-0260. PMID 12663445.
Alto NM, Soderling SH, Hoshi N, et al. (2003). “Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.”. Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
Hornemann T, Kempa S, Himmel M, et al. (2003). “Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein.”. J. Mol. Biol. 332 (4): 877–87. doi:10.1016/S0022-2836(03)00921-5. PMID 12972258.
Dutt P, Nguyen N, Toksoz D (2004). “Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase.”. Cell. Signal. 16 (2): 201–9. doi:10.1016/S0898-6568(03)00132-3. PMID 14636890.
Chen LY, Zuraw BL, Ye RD, Pan ZK (2004). “A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes.”. J. Biol. Chem. 279 (8): 7208–12. doi:10.1074/jbc.M309542200. PMID 14660653.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170776 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066406 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid9627117-5] Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S, Segars J (Jul 1998). “Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action”. Oncogene 16 (19): 2513–26. doi:10.1038/sj.onc.1201783. PMID 9627117.

[pmid1860836-6] Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD (Sep 1991). “Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif”. J Biol Chem 266 (22): 14188–92. PMID 1860836.

[entrez-7] “Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13”. 2012年1月26日閲覧。

[pmid12270917-8] Park, Brian; Nguyen Nhan T, Dutt Parmesh, Merdek Keith D, Bashar Mariam, Sterpetti Paola, Tosolini Alessandra, Testa Joseph R, Toksoz Deniz (Nov. 2002). “Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation”. J. Biol. Chem. (United States) 277 (47): 45361–70. doi:10.1074/jbc.M202447200. ISSN 0021-9258. PMID 12270917.

[pmid12672969-9] Alto, Neal M; Soderling Scott H, Hoshi Naoto, Langeberg Lorene K, Fayos Rosa, Jennings Patricia A, Scott John D (Apr. 2003). “Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring”. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (8): 4445–50. doi:10.1073/pnas.0330734100. ISSN 0027-8424. PMC 153575. PMID 12672969.

[pmid1618839-10] Carr, D W; Hausken Z E, Fraser I D, Stofko-Hahn R E, Scott J D (Jul. 1992). “Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain”. J. Biol. Chem. (UNITED STATES) 267 (19): 13376–82. ISSN 0021-9258. PMID 1618839.

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