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HIF1A

出典: フリー百科事典『ウィキペディア(Wikipedia)』
HIF-1αから転送)
HIF1A
PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧

1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J

識別子
記号HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α
外部IDOMIM: 603348 MGI: 106918 HomoloGene: 1171 GeneCards: HIF1A
遺伝子の位置 (ヒト)
14番染色体 (ヒト)
染色体14番染色体 (ヒト)[1]
14番染色体 (ヒト)
HIF1A遺伝子の位置
HIF1A遺伝子の位置
バンドデータ無し開始点61,695,513 bp[1]
終点61,748,259 bp[1]
遺伝子の位置 (マウス)
12番染色体 (マウス)
染色体12番染色体 (マウス)[2]
12番染色体 (マウス)
HIF1A遺伝子の位置
HIF1A遺伝子の位置
バンドデータ無し開始点73,948,149 bp[2]
終点73,994,304 bp[2]
RNA発現パターン
さらなる参照発現データ
遺伝子オントロジー
分子機能 protein dimerization activity
DNA-binding transcription factor activity
DNA-binding transcription activator activity, RNA polymerase II-specific
ヒストンデアセチラーゼ結合
転写因子結合
酵素結合
血漿タンパク結合
histone acetyltransferase binding
プロテインキナーゼ結合
Hsp90タンパク質結合
sequence-specific DNA binding
DNA結合
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
ubiquitin protein ligase binding
protein heterodimerization activity
E-box binding
p53結合
protein domain specific binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II transcription regulatory region sequence-specific DNA binding
細胞の構成要素 細胞質
細胞質基質
細胞核
nuclear speck
motile cilium
transcription regulator complex
RNA polymerase II transcription regulator complex
axon cytoplasm
核質
核内構造体
高分子複合体
生物学的プロセス negative regulation of neuron apoptotic process
B-1 B cell homeostasis
regulation of transforming growth factor beta2 production
muscle cell cellular homeostasis
outflow tract morphogenesis
negative regulation of ossification
heart looping
negative regulation of TOR signaling
血管発生
ヘモグロビン生合成プロセス
血管新生
positive regulation of chemokine-mediated signaling pathway
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of hormone biosynthetic process
negative regulation of mesenchymal cell apoptotic process
regulation of aerobic respiration
positive regulation of neuroblast proliferation
dopaminergic neuron differentiation
lactate metabolic process
regulation of transcription, DNA-templated
blood vessel morphogenesis
positive regulation of erythrocyte differentiation
glucose homeostasis
vascular endothelial growth factor production
regulation of thymocyte apoptotic process
positive regulation of epithelial cell migration
negative regulation of thymocyte apoptotic process
transcription, DNA-templated
positive regulation of transcription, DNA-templated
axonal transport of mitochondrion
positive regulation of macroautophagy
軟骨形成
positive regulation of nitric-oxide synthase activity
regulation of transcription from RNA polymerase II promoter in response to hypoxia
授乳
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of pri-miRNA transcription by RNA polymerase II
digestive tract morphogenesis
細胞分化
neural fold elevation formation
positive regulation of autophagy
retina vasculature development in camera-type eye
collagen metabolic process
embryonic placenta development
negative regulation of apoptotic process
positive regulation of angiogenesis
regulation of glycolytic process
上皮間葉転換
大脳皮質発生
遺伝子発現調節
positive regulation of chemokine production
intestinal epithelial cell maturation
regulation of catalytic activity
positive regulation of autophagy of mitochondrion
cardiac ventricle morphogenesis
response to muscle activity
epithelial cell differentiation involved in mammary gland alveolus development
visual learning
positive regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of bone mineralization
negative regulation of growth
低酸素症への反応
positive regulation of endothelial cell proliferation
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
iris morphogenesis
mRNA transcription by RNA polymerase II
hypoxia-inducible factor-1alpha signaling pathway
脈管構造発生
regulation of cell population proliferation
neural crest cell migration
embryonic hemopoiesis
connective tissue replacement involved in inflammatory response wound healing
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
negative regulation of reactive oxygen species metabolic process
positive regulation of vascular endothelial growth factor production
elastin metabolic process
positive regulation of glycolytic process
oxygen homeostasis
シグナル伝達
positive regulation of transcription by RNA polymerase II
cellular iron ion homeostasis
camera-type eye morphogenesis
cellular response to hypoxia
cellular response to interleukin-1
transcription by RNA polymerase II
protein deubiquitination
翻訳後修飾
response to iron ion
遺伝子発現の負の調節
positive regulation of blood vessel endothelial cell migration
positive regulation of gene expression
サイトカイン媒介シグナル伝達経路
regulation of transcription by RNA polymerase II
protein ubiquitination
出典:Amigo / QuickGO
オルソログ
ヒトマウス
Entrez
Ensembl
UniProt
RefSeq
(mRNA)

NM_181054
NM_001243084
NM_001530

NM_010431
NM_001313919
NM_001313920

RefSeq
(タンパク質)

NP_001230013
NP_001521
NP_851397
NP_001521.1

NP_001300848
NP_001300849
NP_034561

場所
(UCSC)
Chr 14: 61.7 – 61.75 MbChr 14: 73.95 – 73.99 Mb
PubMed検索[3][4]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

HIF1Aはヘテロ二量体として構成される低酸素誘導因子HIF-1のうちHIF-1αサブユニットをコードしている遺伝子。[5][6][7]

脚注

[編集]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100644 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021109 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
  5. ^ “Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q”. Genomics 34 (3): 437–9. (June 1996). doi:10.1006/geno.1996.0311. PMID 8786149. 
  6. ^ “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. J. Biol. Chem. 272 (13): 8581–93. (March 1997). doi:10.1074/jbc.272.13.8581. PMID 9079689. 
  7. ^ Entrez Gene: HIF1A hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)”. 2017年10月10日閲覧。

参考文献

[編集]
  • “HIF-1 and human disease: one highly involved factor”. Genes Dev. 14 (16): 1983–91. (2000). PMID 10950862. 
  • “Signal transduction to hypoxia-inducible factor 1”. Biochem. Pharmacol. 64 (5–6): 993–8. (2002). doi:10.1016/S0006-2952(02)01168-1. PMID 12213597. 
  • “Quiescent hypervascularity mediated by gain of HIF-1 alpha function”. Cold Spring Harb. Symp. Quant. Biol. 67: 133–42. (2002). doi:10.1101/sqb.2002.67.133. PMID 12858534. 
  • “Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors”. Nat. Rev. Immunol. 5 (9): 712–21. (2005). doi:10.1038/nri1685. PMID 16110315. 
  • “Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes”. Histol. Histopathol. 20 (4): 1327–38. (2005). PMID 16136514. 
  • “Hypoxia and HIF-1 alpha in chondrogenesis”. Semin. Cell Dev. Biol. 16 (4–5): 539–46. (2006). doi:10.1016/j.semcdb.2005.03.003. PMID 16144691. 
  • “Hypoxia-inducible factors in the kidney”. Am. J. Physiol. Renal Physiol. 291 (2): F271-81. (2006). doi:10.1152/ajprenal.00071.2006. PMID 16554418. 
  • “Effects of histone deacetylase inhibitors on HIF-1”. Cell Cycle 5 (21): 2430–5. (2006). doi:10.4161/cc.5.21.3409. PMID 17102633.