Template:PBB/6622

シヌクレイン, アルファ (アミロイド前駆体の非A4成分); Synuclein, alpha (non A4 component of amyloid precursor)
	PDB1xq8からの画像
PDBに登録されている構造
PDB	Ortholog search: PDBe, RCSB, PDBj
PDBのIDコード一覧
	1XQ8, 2JN5, 2KKW, 2X6M, 3Q25, 3Q26, 3Q27, 3Q28, 3Q29
識別記号
記号	SNCA; NACP; PARK1; PARK4; PD1
その他ID	OMIM: 163890 MGI（英語版）: 1277151 HomoloGene（英語版）: 293 ChEMBL: 6152 GeneCards: SNCA Gene
遺伝子オントロジー
分子機能	• magnesium ion binding; • fatty acid binding; • copper ion binding; • calcium ion binding; • protein binding; • ferrous iron binding; • zinc ion binding; • oxidoreductase activity; • kinesin binding; • Hsp70 protein binding; • histone binding; • identical protein binding; • alpha-tubulin binding; • cysteine-type endopeptidase inhibitor activity involved in apoptotic process; • dynein binding; • tau protein binding; • phosphoprotein binding; • phospholipase D inhibitor activity;
細胞の構成要素	• extracellular region; • nucleus; • cytoplasm; • mitochondrion; • cytosol; • plasma membrane; • cell cortex; • actin cytoskeleton; • inclusion body; • cell junction; • axon; • growth cone; • platelet alpha granule membrane; • fibril; • synapse; • perinuclear region of cytoplasm;
生物学的プロセス	• microglial cell activation; • positive regulation of receptor recycling; • positive regulation of neurotransmitter secretion; • fatty acid metabolic process; • neutral lipid metabolic process; • phospholipid metabolic process; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • mitochondrial membrane organization; • adult locomotory behavior; • response to iron(II) ion; • regulation of phospholipase activity; • negative regulation of platelet-derived growth factor receptor signaling pathway; • regulation of glutamate secretion; • regulation of dopamine secretion; • negative regulation of microtubule polymerization; • receptor internalization; • protein destabilization; • response to magnesium ion; • negative regulation of transporter activity; • response to lipopolysaccharide; • negative regulation of monooxygenase activity; • positive regulation of peptidyl-serine phosphorylation; • response to interferon-gamma; • cellular response to oxidative stress; • negative regulation of histone acetylation; • regulation of locomotion; • dopamine biosynthetic process; • response to drug; • mitochondrial ATP synthesis coupled electron transport; • regulation of macrophage activation; • negative regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • extracellular fibril organization; • negative regulation of neuron apoptotic process; • positive regulation of endocytosis; • negative regulation of exocytosis; • regulation of long-term neuronal synaptic plasticity; • synaptic vesicle endocytosis; • synapse organization; • regulation of acyl-CoA biosynthetic process; • positive regulation of release of sequestered calcium ion into cytosol; • dopamine uptake involved in synaptic transmission; • negative regulation of dopamine uptake involved in synaptic transmission; • negative regulation of serotonin uptake; • negative regulation of norepinephrine uptake; • calcium ion homeostasis; • oxidation-reduction process; • regulation of excitatory postsynaptic membrane potential; • long-term synaptic potentiation; • positive regulation of inositol phosphate biosynthetic process; • negative regulation of thrombin receptor signaling pathway; • response to interleukin-1; • cellular response to copper ion; • cellular response to epinephrine stimulus; • positive regulation of protein serine/threonine kinase activity;
	出典: Amigo / EGO
RNA発現パターン
	その他参照発現データ
オルソログ
	表; 話; 編; 歴;

^ Ulmer TS, Bax A, Cole NB, Nussbaum RL (Mar 2005). “Structure and dynamics of micelle-bound human alpha-synuclein”. J Biol Chem 280 (10): 9595-9603. doi:10.1074/jbc.M411805200. PMID 15615727.

[1] Ulmer TS, Bax A, Cole NB, Nussbaum RL (Mar 2005). “Structure and dynamics of micelle-bound human alpha-synuclein”. J Biol Chem 280 (10): 9595-9603. doi:10.1074/jbc.M411805200. PMID 15615727.

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