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Template:PBB/7157

Tumor protein p53
PDB rendering based on 1TUP: P53 complexed with DNA[1]
PDBに登録されている構造
PDB Ortholog search: PDBe, RCSB, PDBj
PDBのIDコード一覧

1A1U​, 1AIE​, 1C26​, 1DT7​, 1GZH​, 1H26​, 1HS5​, 1JSP​, 1KZY​, 1MA3​, 1OLG​, 1OLH​, 1PES​, 1PET​, 1SAE​, 1SAF​, 1SAK​, 1SAL​, 1TSR​, 1TUP​, 1UOL​, 1XQH​, 1YC5​, 1YCQ​, 1YCR​, 1YCS​, 2AC0​, 2ADY​, 2AHI​, 2ATA​, 2B3G​, 2BIM​, 2BIN​, 2BIO​, 2BIP​, 2BIQ​, 2FEJ​, 2FOJ​, 2FOO​, 2GS0​, 2H1L​, 2H2D​, 2H2F​, 2H4F​, 2H4H​, 2H4J​, 2H59​, 2J0Z​, 2J10​, 2J11​, 2J1W​, 2J1X​, 2J1Y​, 2J1Z​, 2J20​, 2J21​, 2K8F​, 2L14​, 2OCJ​, 2PCX​, 2QVQ​, 2QXA​, 2QXB​, 2QXC​, 2VUK​, 2WGX​, 2X0U​, 2X0V​, 2X0W​, 2XWR​, 2YBG​, 2Z5S​, 2Z5T​, 3D05​, 3D06​, 3D07​, 3D08​, 3D09​, 3D0A​, 3DAB​, 3DAC​, 3IGK​, 3IGL​, 3KMD​, 3KZ8​, 3LW1​, 3PDH​, 3Q01​, 3Q05​, 3Q06​, 3SAK​, 3TG5​, 3TS8​, 4AGL​, 4AGM​, 4AGN​, 4AGO​, 4AGP​, 4AGQ

識別記号
記号 TP53; LFS1; P53; TRP53
その他ID OMIM191170 MGI英語版98834 HomoloGene英語版460 ChEMBL: 4096 GeneCards: TP53 Gene
遺伝子オントロジー
分子機能 DNA strand annealing activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
RNA polymerase II transcription factor binding
protease binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
sequence-specific DNA binding transcription factor activity
copper ion binding
protein binding
ATP binding
transcription factor binding
zinc ion binding
enzyme binding
protein kinase binding
ubiquitin protein ligase binding
histone deacetylase regulator activity
histone acetyltransferase binding
identical protein binding
transcription regulatory region DNA binding
metal ion binding
protein heterodimerization activity
protein N-terminus binding
chaperone binding
protein phosphatase 2A binding
MDM2 binding
細胞の構成要素 chromatin
nuclear chromatin
insoluble fraction
nucleus
nucleoplasm
nucleoplasm
replication fork
transcription factor TFIID complex
chromatin assembly complex
nucleolus
cytoplasm
mitochondrion
endoplasmic reticulum
cytosol
cytosol
nuclear matrix
nuclear body
PML body
protein complex
生物学的プロセス protein import into nucleus, translocation
cell cycle checkpoint
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
DNA strand renaturation
in utero embryonic development
somitogenesis
T cell proliferation involved in immune response
B cell lineage commitment
T cell lineage commitment
base-excision repair
nucleotide-excision repair
double-strand break repair
regulation of transcription, DNA-dependent
protein complex assembly
apoptotic process
apoptotic process
response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
ER overload response
cell cycle arrest
cell cycle arrest
Ras protein signal transduction
multicellular organismal development
gastrulation
negative regulation of neuroblast proliferation
central nervous system development
cell aging
blood coagulation
protein localization
negative regulation of DNA replication
cell proliferation
negative regulation of cell proliferation
determination of adult lifespan
induction of apoptosis by intracellular signals
rRNA transcription
response to salt stress
embryo development ending in birth or egg hatching
response to X-ray
response to gamma radiation
cell differentiation
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
DNA damage response, signal transduction by p53 class mediator
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of histone deacetylation
mitotic cell cycle G1/S transition DNA damage checkpoint
positive regulation of protein oligomerization
T cell differentiation in thymus
cellular protein localization
cellular response to UV
multicellular organism growth
cellular response to drug
cellular response to glucose starvation
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of neuron apoptosis
interspecies interaction between organisms
negative regulation of transcription, DNA-dependent
positive regulation of transcription, DNA-dependent
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
regulation of mitochondrial membrane permeability
negative regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
regulation of catalytic activity
negative regulation of helicase activity
protein tetramerization
chromosome organization
regulation of cell cycle
positive regulation of thymocyte apoptosis
positive regulation of cell cycle arrest
cellular response to hypoxia
cellular response to ionizing radiation
signal transduction by p53 class mediator resulting in induction of apoptosis
positive regulation of release of cytochrome c from mitochondria
positive regulation of cell aging
replicative senescence
oxidative stress-induced premature senescence
positive regulation of reactive oxygen species metabolic process
positive regulation of intrinsic apoptotic signaling pathway
出典: Amigo / EGO
RNA発現パターン
その他参照発現データ
オルソログ
ヒト マウス
Entrez英語版 7157 22059
Ensembl英語版 ENSG00000141510 ENSMUSG00000059552
UniProt英語版 P04637 P02340
RefSeq (mRNA) NM_000546.5 NM_001127233.1
RefSeq (protein) NP_000537.3 NP_001120705.1
Location (UCSC) Chr 17:
7.57 - 7.59 Mb
Chr 11:
69.39 - 69.41 Mb
PubMed search [1] [2]
KEGG GENES hsa:7157 mmu:22059
  1. ^ Cho Y, Gorina S, Jeffrey PD, Pavletich NP (1994). “Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations”. Science 265 (5170): 346-355. doi:10.1126/science.8023157. PMID 8023157.