γ-グルタミルヒドロラーゼ
γ-グルタミルヒドロラーゼ(Gamma-glutamyl hydrolase)は、以下の化学反応を触媒する酵素である[1][2][3][4]。
- γ-グルタミル結合を加水分解する。
リソソーム型または分泌型のチオール依存性ペプチダーゼであり、酸性で最も活性が高い。
ヒトでは、GGH遺伝子でコードされ[3][5][6]、γ-結合ポリグルタミン酸やグルタミン酸を除去することで、ポリグルタミン酸型葉酸やポリグルタミン酸化された葉酸拮抗薬を加水分解する[6]。
相互作用経路
[編集]遺伝子、蛋白質、代謝物の名称をクリックすると其々の項目（主に英語版）が開きます。 [§ 1]
5-フルオロウラシル（5-FU）の活性 編集
- ^ The interactive pathway map can be edited at WikiPathways: “FluoropyrimidineActivity_WP1601”. 2016年5月1日閲覧。
出典
[編集]- ^ “The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells”. Biochim. Biophys. Acta 1164 (3): 227–35. (August 1993). doi:10.1016/0167-4838(93)90253-n. PMID 8343522.
- ^ “Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells”. Mol. Pharmacol. 48 (3): 505–11. (September 1995). PMID 7565632.
- ^ a b “Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro”. Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10134–8. (September 1996). doi:10.1073/pnas.93.19.10134. PMC 38349. PMID 8816764.
- ^ “Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase”. J. Biol. Chem. 271 (15): 8525–8. (April 1996). doi:10.1074/jbc.271.15.8525. PMID 8621474.
- ^ “Structural organization of the human gamma-glutamyl hydrolase gene”. Gene 238 (2): 463–70. (Dec 1999). doi:10.1016/S0378-1119(99)00362-5. PMID 10570974.
- ^ a b “Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)”. 2022年10月14日閲覧。
関連文献
[編集]- “Glutamyl hydrolase: properties and pharmacologic impact”. Semin. Oncol. 26 (2 Suppl 6): 33–7. (1999). PMID 10598552.
- “Secretion of gamma-glutamyl hydrolase in vitro”. Cancer Res. 51 (15): 3874–81. (1991). PMID 1713122.
- “Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization”. J. Biol. Chem. 261 (2): 928–33. (1986). doi:10.1016/S0021-9258(17)36185-9. PMID 2867095.
- “Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization”. J. Biol. Chem. 261 (29): 13551–5. (1986). doi:10.1016/S0021-9258(18)67054-1. PMID 3759978.
- “Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase”. J. Biol. Chem. 271 (15): 8525–8. (1996). doi:10.1074/jbc.271.15.8525. PMID 8621474.
- “Characterization of human cellular gamma-glutamyl hydrolase”. Mol. Pharmacol. 53 (6): 1040–6. (1998). PMID 9614206.
- “Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate”. J. Biol. Chem. 277 (27): 24522–9. (2002). doi:10.1074/jbc.M202020200. PMID 11953431.
- “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- “Proteomic analysis of early melanosomes: identification of novel melanosomal proteins”. J. Proteome Res. 2 (1): 69–79. (2003). doi:10.1021/pr025562r. PMID 12643545.
- “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. (2004). doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- “Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray”. Hum. Pathol. 35 (10): 1196–209. (2004). doi:10.1016/j.humpath.2004.06.014. PMID 15492986.
- “Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. (2005). doi:10.1038/nature04209. PMID 16189514.
- “Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer”. Biochim. Biophys. Acta 1764 (9): 1479–86. (2006). doi:10.1016/j.bbapap.2006.06.008. PMID 16945597.
- “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes”. J. Proteome Res. 5 (11): 3135–44. (2007). doi:10.1021/pr060363j. PMID 17081065.
- “Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population”. Biol. Pharm. Bull. 30 (4): 839–41. (2007). doi:10.1248/bpb.30.839. PMID 17409534.
外部リンク
[編集]- Gamma-glutamyl hydrolase - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス
- Overview of all the structural information available in the PDB for UniProt: Q92820 (Gamma-glutamyl hydrolase) at the PDBe-KB.