ホスファチジルイノシトール-3,4,5-三リン酸 5-ホスファターゼ

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ホスファチジルイノシトール-3,4,5-三リン酸-5-ホスファターゼ
識別子
EC番号	3.1.3.86
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索
PMC	articles
PubMed	articles
NCBI	proteins
	テンプレートを表示

ホスファチジルイノシトール-3,4,5-三リン酸-5-ホスファターゼ(Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase、EC 3.1.3.86)は、1-ホスファチジル-1D-ミオイノシトール-3,4,5-三リン酸-5-ホスファターゼ(1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase)という系統名を持つ酵素である^[1]^[2]^[3]^[4]^[5]。以下の化学反応を触媒する。

1-ホスファチジル-1D-ミオイノシトール-3,4,5-三リン酸 + 水

\rightleftharpoons

1-ホスファチジル-1D-ミオイノシトール-3,4-二リン酸 + リン酸

出典

^ Lioubin, M.N., Algate, P.A., Tsai, S., Carlberg, K., Aebersold, A. and Rohrschneider, L.R. (1996). “p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity”. Genes Dev. 10: 1084–1095. doi:10.1101/gad.10.9.1084. PMID 8654924.
^ Damen, J.E., Liu, L., Rosten, P., Humphries, R.K., Jefferson, A.B., Majerus, P.W. and Krystal, G. (1996). “The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase”. Proc. Natl. Acad. Sci. USA 93: 1689–1693. doi:10.1073/pnas.93.4.1689. PMC 40003. PMID 8643691.
^ Giuriato, S., Payrastre, B., Drayer, A.L., Plantavid, M., Woscholski, R., Parker, P., Erneux, C. and Chap, H. (1997). “Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets”. J. Biol. Chem. 272: 26857–26863. doi:10.1074/jbc.272.43.26857. PMID 9341117.
^ Drayer, A.L., Pesesse, X., De Smedt, F., Woscholski, R., Parker, P. and Erneux, C. (1996). “Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase”. Biochem. Biophys. Res. Commun. 225: 243–249. doi:10.1006/bbrc.1996.1161. PMID 8769125.
^ Pesesse, X., Moreau, C., Drayer, A.L., Woscholski, R., Parker, P. and Erneux, C. (1998). “The SH₂ domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity”. FEBS Lett. 437 (3): 301–303. doi:10.1016/S0014-5793(98)01255-1. PMID 9824312.

外部リンク

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

[1] Lioubin, M.N., Algate, P.A., Tsai, S., Carlberg, K., Aebersold, A. and Rohrschneider, L.R. (1996). “p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity”. Genes Dev. 10: 1084–1095. doi:10.1101/gad.10.9.1084. PMID 8654924.

[2] Damen, J.E., Liu, L., Rosten, P., Humphries, R.K., Jefferson, A.B., Majerus, P.W. and Krystal, G. (1996). “The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase”. Proc. Natl. Acad. Sci. USA 93: 1689–1693. doi:10.1073/pnas.93.4.1689. PMC 40003. PMID 8643691.

[3] Giuriato, S., Payrastre, B., Drayer, A.L., Plantavid, M., Woscholski, R., Parker, P., Erneux, C. and Chap, H. (1997). “Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets”. J. Biol. Chem. 272: 26857–26863. doi:10.1074/jbc.272.43.26857. PMID 9341117.

[4] Drayer, A.L., Pesesse, X., De Smedt, F., Woscholski, R., Parker, P. and Erneux, C. (1996). “Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase”. Biochem. Biophys. Res. Commun. 225: 243–249. doi:10.1006/bbrc.1996.1161. PMID 8769125.

[5] Pesesse, X., Moreau, C., Drayer, A.L., Woscholski, R., Parker, P. and Erneux, C. (1998). “The SH₂ domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity”. FEBS Lett. 437 (3): 301–303. doi:10.1016/S0014-5793(98)01255-1. PMID 9824312.

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