レテプリニム

レテプリニム
IUPAC命名法による物質名
	IUPAC名 4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid;
データベースID
CAS番号;	138117-50-7
ATCコード	none
PubChem	CID: 132123
ChemSpider	116710
UNII	NBY3IU407M
化学的データ
化学式	C15H13N5O4
分子量	327.295
	SMILES C1=CC(=CC=C1C(=O)O)NC(=O)CCN2C=NC3=C2NC=NC3=O;
	InChI InChI=1S/C15H13N5O4/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22); Key:JMPOIZCOJJMTHI-UHFFFAOYSA-N;
	テンプレートを表示

レテプリニム（英: Leteprinim; Neotrofin, AIT-082）は、神経保護作用と向知性作用を持つヒポキサンチン誘導体薬^[1]^[2]^[3] 。神経成長因子の放出を刺激し、脳内のニューロンの生存を促進するとされており^[4]^[5]^[6] ^[7] ^[8]、アルツハイマー病、パーキンソン病、脳梗塞^[9]^[10]の治療薬となることが期待されている。

脚注

^ “AIT-082 is neuroprotective against kainate-induced neuronal injury in rats”. Experimental Neurology 169 (2): 392–9. (June 2001). doi:10.1006/exnr.2001.7654. PMID 113584526
^ “Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin”. Annals of the New York Academy of Sciences 903 (1): 387–93. (April 2000). Bibcode: 2000NYASA.903..387L. doi:10.1111/j.1749-6632.2000.tb06390.x. PMID 10818529.
^ “Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones”. Psychopharmacology 166 (4): 400–7. (April 2003). doi:10.1007/s00213-002-1350-5. PMID 12605287.
^ “AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury”. Expert Opinion on Investigational Drugs 8 (8): 1255–62. (August 1999). doi:10.1517/13543784.8.8.1255. PMID 159921496
^ “The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats”. Restorative Neurology and Neuroscience 20 (1–2): 51–9. (2002). PMID 12237496.
^ “Neotrofin, a novel purine that induces NGF-dependent nociceptive nerve sprouting but not hyperalgesia in adult rat skin”. Molecular and Cellular Neurosciences 24 (3): 568–80. (November 2003). doi:10.1016/s1044-7431(03)00217-3. PMID 14664808.
^ “AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats”. International Journal of Immunopathology and Pharmacology 17 (3): 353–66. (2004). doi:10.1177/039463200401700315. PMID 154618696
^ “Protection of sensory function in diabetic rats by Neotrofin”. European Journal of Pharmacology 534 (1–3): 187–93. (March 2006). doi:10.1016/j.ejphar.2006.01.047. PMID 16507305.
^ “Brain metabolic effects of Neotrofin in patients with Alzheimer's disease”. Brain Research 951 (1): 87–95. (September 2002). doi:10.1016/s0006-8993(02)03140-2. PMID 12231461.
^ “Drugs in development for Parkinson's disease”. Current Opinion in Investigational Drugs 5 (7): 720–6. (July 2004). PMID 15298067.

外部リンク

レテプリニムカリウム-AdisInsight

[1] “AIT-082 is neuroprotective against kainate-induced neuronal injury in rats”. Experimental Neurology 169 (2): 392–9. (June 2001). doi:10.1006/exnr.2001.7654. PMID 113584526

[2] “Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin”. Annals of the New York Academy of Sciences 903 (1): 387–93. (April 2000). Bibcode: 2000NYASA.903..387L. doi:10.1111/j.1749-6632.2000.tb06390.x. PMID 10818529.

[3] “Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones”. Psychopharmacology 166 (4): 400–7. (April 2003). doi:10.1007/s00213-002-1350-5. PMID 12605287.

[4] “AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury”. Expert Opinion on Investigational Drugs 8 (8): 1255–62. (August 1999). doi:10.1517/13543784.8.8.1255. PMID 159921496

[5] “The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats”. Restorative Neurology and Neuroscience 20 (1–2): 51–9. (2002). PMID 12237496.

[6] “Neotrofin, a novel purine that induces NGF-dependent nociceptive nerve sprouting but not hyperalgesia in adult rat skin”. Molecular and Cellular Neurosciences 24 (3): 568–80. (November 2003). doi:10.1016/s1044-7431(03)00217-3. PMID 14664808.

[7] “AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats”. International Journal of Immunopathology and Pharmacology 17 (3): 353–66. (2004). doi:10.1177/039463200401700315. PMID 154618696

[8] “Protection of sensory function in diabetic rats by Neotrofin”. European Journal of Pharmacology 534 (1–3): 187–93. (March 2006). doi:10.1016/j.ejphar.2006.01.047. PMID 16507305.

[9] “Brain metabolic effects of Neotrofin in patients with Alzheimer's disease”. Brain Research 951 (1): 87–95. (September 2002). doi:10.1016/s0006-8993(02)03140-2. PMID 12231461.

[10] “Drugs in development for Parkinson's disease”. Current Opinion in Investigational Drugs 5 (7): 720–6. (July 2004). PMID 15298067.

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