血清応答因子

SRF
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1HBX, 1K6O, 1SRS
識別子
記号	SRF, MCM1, serum response factor
外部ID	OMIM: 600589 MGI: 106658 HomoloGene: 31135 GeneCards: SRF
遺伝子の位置 (ヒト)
染色体	6番染色体 (ヒト)
終点	43,181,506 bp
遺伝子の位置 (マウス)
染色体	17番染色体 (マウス)
終点	46,867,101 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• protein dimerization activity; • DNA-binding transcription factor activity; • DNA-binding transcription activator activity, RNA polymerase II-specific; • RNA polymerase II general transcription initiation factor activity; • primary miRNA binding; • 転写因子結合; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • protein homodimerization activity; • serum response element binding; • クロマチン結合; • 血漿タンパク結合; • DNA結合; • sequence-specific DNA binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • chromatin DNA binding; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • cis-regulatory region sequence-specific DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • ヒストンデアセチラーゼ結合; • RNA polymerase II-specific DNA-binding transcription factor binding;
細胞の構成要素	• 細胞質; • 細胞核; • 核質;
生物学的プロセス	• dorsal aorta morphogenesis; • 気管支軟骨発生; • muscle cell cellular homeostasis; • lung smooth muscle development; • regulation of water loss via skin; • transcription by RNA polymerase II; • stress fiber assembly; • cell migration involved in sprouting angiogenesis; • platelet activation; • cardiac myofibril assembly; • heart looping; • 細胞老化; • face development; • regulation of cell adhesion; • 長期抑圧; • neuron projection development; • morphogenesis of an epithelial sheet; • positive regulation of filopodium assembly; • primitive streak formation; • cellular response to glucose stimulus; • negative regulation of cell population proliferation; • response to cytokine; • regulation of transcription, DNA-templated; • heart trabecula formation; • actin filament organization; • 胸腺発生; • angiogenesis involved in wound healing; • 血小板形成; • neuron development; • in utero embryonic development; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • 心臓発生; • positive regulation of cell differentiation; • branching involved in blood vessel morphogenesis; • positive regulation of axon extension; • positive regulation of smooth muscle contraction; • 気管軟骨発生; • 毒性物質への反応; • positive regulation of pri-miRNA transcription by RNA polymerase II; • positive regulation of transcription by glucose; • regulation of smooth muscle cell differentiation; • epithelial structure maintenance; • associative learning; • skin morphogenesis; • positive regulation of DNA-binding transcription factor activity; • epithelial cell-cell adhesion; • neuron migration; • positive regulation of transcription initiation from RNA polymerase II promoter; • eyelid development in camera-type eye; • 甲状腺発生; • negative regulation of amyloid-beta clearance; • negative regulation of cell migration; • developmental growth; • hematopoietic stem cell differentiation; • 原腸形成; • trophectodermal cell differentiation; • positive thymic T cell selection; • ホルモンへの反応; • cell-matrix adhesion; • sarcomere organization; • actin cytoskeleton organization; • megakaryocyte development; • 低酸素症への反応; • lung morphogenesis; • mesoderm formation; • cardiac vascular smooth muscle cell differentiation; • mRNA transcription by RNA polymerase II; • 多細胞個体の発生; • tangential migration from the subventricular zone to the olfactory bulb; • 長期記憶; • contractile actin filament bundle assembly; • bicellular tight junction assembly; • leukocyte differentiation; • 海馬発生; • positive regulation of transcription by RNA polymerase II; • erythrocyte development; • negative regulation of pri-miRNA transcription by RNA polymerase II; • 前脳発生; • cell-cell adhesion;
	出典:Amigo / QuickGO
オルソログ
	6722
	20807
	ENSG00000112658
	ENSMUSG00000015605
	P11831,A0A024RD16
	Q9JM73
	NM_003131; NM_001292001
	NM_020493
	NP_001278930; NP_003122; NP_003122.1
	NP_065239
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

血清応答因子（けっせいおうとういんし、英: serum response factor、略称: SRF）は、転写因子として機能するタンパク質である^[5]。

機能

血清応答因子はMADSボックススーパーファミリーに属する転写因子である^[6]。このタンパク質は、標的遺伝子のプロモーター内の血清応答エレメント（serum response element; SRE）に結合する。このタンパク質はc-fosを含む多くの最初期遺伝子の活性を調節しており、それによって細胞周期の調節、アポトーシス、細胞成長、細胞分化に関与している。SRFは多くのシグナル伝達経路の下流の標的となっており、一例としてMAPK経路はTCFファミリー（ternary complex factor）を介してSRFの転写活性を調節する^[7]^[8]。

SRFは胚発生時に重要であり、中胚葉の形成と関連づけられている^[9]^[10]。完全に発達した哺乳類では、SRFは骨格筋の成長に重要である^[11]。SRFとステロイドホルモン受容体（英語版）などとの相互作用は、ステロイドによる筋成長の調節に寄与している可能性がある^[12]。またELK1（英語版）などのTCFとミオカルディン（英語版）はSRFをめぐって競合し、それぞれ平滑筋遺伝子の発現を抑制、促進する^[13]。

臨床的意義

SRFの欠損は乾癬やその他の皮膚疾患と関連している^[14]。

相互作用

SRFは次に挙げる因子と相互作用することが示されている。

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112658 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015605 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element”. Cell 55 (6): 989–1003. (December 1988). doi:10.1016/0092-8674(88)90244-9. PMID 3203386.
^ “The MADS-box family of transcription factors”. Eur. J. Biochem. 229 (1): 1–13. (April 1995). doi:10.1111/j.1432-1033.1995.0001l.x. PMID 7744019.
^ “Isolation and characterization of SRF accessory proteins”. Philos. Trans. R. Soc. Lond. B Biol. Sci. 340 (1293): 325–32. (June 1993). Bibcode: 1993RSPTB.340..325D. doi:10.1098/rstb.1993.0074. PMID 8103935.
^ “SRF serum response factor [Homo sapiens (human) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2024年10月5日閲覧。
^ “Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity”. J. Biol. Chem. 277 (28): 25775–82. (July 2002). doi:10.1074/jbc.M203122200. PMID 11983708.
^ “Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes”. J. Biol. Chem. 280 (12): 11816–28. (March 2005). doi:10.1074/jbc.M412408200. PMID 15591049.
^ “Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice”. Proc. Natl. Acad. Sci. U.S.A. 102 (4): 1082–7. (January 2005). Bibcode: 2005PNAS..102.1082L. doi:10.1073/pnas.0409103102. PMC 545866. PMID 15647354.
^ “Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene”. J. Biol. Chem. 280 (9): 7786–92. (March 2005). doi:10.1074/jbc.M413992200. PMID 15623502.
^ Wang, Zhigao; Wang, Da-Zhi; Hockemeyer, Dirk; McAnally, John; Nordheim, Alfred; Olson, Eric N. (2004-03-11). “Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression”. Nature 428 (6979): 185–189. doi:10.1038/nature02382. ISSN 1476-4687. PMID 15014501.
^ “Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice”. J. Clin. Invest. 119 (4): 899–910. (April 2009). doi:10.1172/JCI37771. PMC 2662566. PMID 19307725.
^ “Novel transcription coactivator complex containing activating signal cointegrator 1”. Mol. Cell. Biol. 22 (14): 5203–11. (July 2002). doi:10.1128/mcb.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
^ ^a ^b “Interaction of ATF6 and serum response factor”. Mol. Cell. Biol. 17 (9): 4957–66. (September 1997). doi:10.1128/MCB.17.9.4957. PMC 232347. PMID 9271374.
^ “Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta”. J. Biol. Chem. 274 (20): 14224–8. (May 1999). doi:10.1074/jbc.274.20.14224. PMID 10318842.
^ “Regulation of the cfos serum response element by C/EBPbeta”. Mol. Cell. Biol. 17 (3): 1744–55. (March 1997). doi:10.1128/mcb.17.3.1744. PMC 231899. PMID 9032301.
^ ^a ^b “PML-nuclear bodies are involved in cellular serum response”. Genes Cells 8 (3): 275–86. (March 2003). doi:10.1046/j.1365-2443.2003.00632.x. PMID 12622724.
^ “The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex”. EMBO J. 20 (12): 3018–28. (June 2001). doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.
^ “Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators”. Mol. Cell. Biol. 20 (20): 7550–8. (October 2000). doi:10.1128/mcb.20.20.7550-7558.2000. PMC 86307. PMID 11003651.
^ “Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor”. Mol. Cell. Biol. 21 (4): 1036–44. (February 2001). doi:10.1128/MCB.21.4.1036-1044.2001. PMC 99558. PMID 11158291.
^ “Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor”. Nature 373 (6515): 632–5. (February 1995). Bibcode: 1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423.
^ “Role of transcription factor TFIIF in serum response factor-activated transcription”. J. Biol. Chem. 269 (5): 3489–97. (February 1994). doi:10.1016/S0021-9258(17)41889-8. PMID 8106390.
^ “A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I”. Genes Dev. 11 (19): 2482–93. (October 1997). doi:10.1101/gad.11.19.2482. PMC 316568. PMID 9334314.
^ “TFII-I enhances activation of the c-fos promoter through interactions with upstream elements”. Mol. Cell. Biol. 18 (6): 3310–20. (June 1998). doi:10.1128/mcb.18.6.3310. PMC 108912. PMID 9584171.
^ “Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins”. J. Biol. Chem. 271 (9): 5258–64. (March 1996). doi:10.1074/jbc.271.9.5258. PMID 8617811.
^ “Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter”. Mol. Cell. Biol. 19 (4): 2577–84. (April 1999). doi:10.1128/MCB.19.4.2577. PMC 84050. PMID 10082523.
^ “Identification of proteins that interact with NF-YA”. FEBS Lett. 460 (1): 41–5. (October 1999). Bibcode: 1999FEBSL.460...41Y. doi:10.1016/s0014-5793(99)01311-3. PMID 10571058.
^ “Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor”. J. Biol. Chem. 275 (17): 12470–4. (April 2000). doi:10.1074/jbc.275.17.12470. PMID 10777532.
^ “Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations”. J. Biol. Chem. 273 (44): 28564–7. (October 1998). doi:10.1074/jbc.273.44.28564. PMID 9786846.
^ “Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1”. J. Biol. Chem. 276 (13): 10413–22. (March 2001). doi:10.1074/jbc.M008625200. PMID 11136726.

外部リンク

Serum Response Factor - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）
FactorBook SRF

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112658 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015605 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid3203386-5] “Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element”. Cell 55 (6): 989–1003. (December 1988). doi:10.1016/0092-8674(88)90244-9. PMID 3203386.

[pmid7744019-6] “The MADS-box family of transcription factors”. Eur. J. Biochem. 229 (1): 1–13. (April 1995). doi:10.1111/j.1432-1033.1995.0001l.x. PMID 7744019.

[pmid8103935-7] “Isolation and characterization of SRF accessory proteins”. Philos. Trans. R. Soc. Lond. B Biol. Sci. 340 (1293): 325–32. (June 1993). Bibcode: 1993RSPTB.340..325D. doi:10.1098/rstb.1993.0074. PMID 8103935.

[8] “SRF serum response factor [Homo sapiens (human) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2024年10月5日閲覧。

[pmid11983708-9] “Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity”. J. Biol. Chem. 277 (28): 25775–82. (July 2002). doi:10.1074/jbc.M203122200. PMID 11983708.

[pmid15591049-10] “Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes”. J. Biol. Chem. 280 (12): 11816–28. (March 2005). doi:10.1074/jbc.M412408200. PMID 15591049.

[pmid15647354-11] “Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice”. Proc. Natl. Acad. Sci. U.S.A. 102 (4): 1082–7. (January 2005). Bibcode: 2005PNAS..102.1082L. doi:10.1073/pnas.0409103102. PMC 545866. PMID 15647354.

[pmid15623502-12] “Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene”. J. Biol. Chem. 280 (9): 7786–92. (March 2005). doi:10.1074/jbc.M413992200. PMID 15623502.

[13] Wang, Zhigao; Wang, Da-Zhi; Hockemeyer, Dirk; McAnally, John; Nordheim, Alfred; Olson, Eric N. (2004-03-11). “Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression”. Nature 428 (6979): 185–189. doi:10.1038/nature02382. ISSN 1476-4687. PMID 15014501.

[pmid19307725-14] “Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice”. J. Clin. Invest. 119 (4): 899–910. (April 2009). doi:10.1172/JCI37771. PMC 2662566. PMID 19307725.

[pmid12077347-15] “Novel transcription coactivator complex containing activating signal cointegrator 1”. Mol. Cell. Biol. 22 (14): 5203–11. (July 2002). doi:10.1128/mcb.22.14.5203-5211.2002. PMC 139772. PMID 12077347.

[pmid9271374-16] “Interaction of ATF6 and serum response factor”. Mol. Cell. Biol. 17 (9): 4957–66. (September 1997). doi:10.1128/MCB.17.9.4957. PMC 232347. PMID 9271374.

[pmid10318842-17] “Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta”. J. Biol. Chem. 274 (20): 14224–8. (May 1999). doi:10.1074/jbc.274.20.14224. PMID 10318842.

[pmid9032301-18] “Regulation of the cfos serum response element by C/EBPbeta”. Mol. Cell. Biol. 17 (3): 1744–55. (March 1997). doi:10.1128/mcb.17.3.1744. PMC 231899. PMID 9032301.

[pmid12622724-19] “PML-nuclear bodies are involved in cellular serum response”. Genes Cells 8 (3): 275–86. (March 2003). doi:10.1046/j.1365-2443.2003.00632.x. PMID 12622724.

[pmid11406578-20] “The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex”. EMBO J. 20 (12): 3018–28. (June 2001). doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.

[pmid11003651-21] “Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators”. Mol. Cell. Biol. 20 (20): 7550–8. (October 2000). doi:10.1128/mcb.20.20.7550-7558.2000. PMC 86307. PMID 11003651.

[pmid11158291-22] “Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor”. Mol. Cell. Biol. 21 (4): 1036–44. (February 2001). doi:10.1128/MCB.21.4.1036-1044.2001. PMC 99558. PMID 11158291.

[pmid7854423-23] “Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor”. Nature 373 (6515): 632–5. (February 1995). Bibcode: 1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423.

[pmid8106390-24] “Role of transcription factor TFIIF in serum response factor-activated transcription”. J. Biol. Chem. 269 (5): 3489–97. (February 1994). doi:10.1016/S0021-9258(17)41889-8. PMID 8106390.

[pmid9334314-25] “A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I”. Genes Dev. 11 (19): 2482–93. (October 1997). doi:10.1101/gad.11.19.2482. PMC 316568. PMID 9334314.

[pmid9584171-26] “TFII-I enhances activation of the c-fos promoter through interactions with upstream elements”. Mol. Cell. Biol. 18 (6): 3310–20. (June 1998). doi:10.1128/mcb.18.6.3310. PMC 108912. PMID 9584171.

[pmid8617811-27] “Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins”. J. Biol. Chem. 271 (9): 5258–64. (March 1996). doi:10.1074/jbc.271.9.5258. PMID 8617811.

[pmid10082523-28] “Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter”. Mol. Cell. Biol. 19 (4): 2577–84. (April 1999). doi:10.1128/MCB.19.4.2577. PMC 84050. PMID 10082523.

[pmid10571058-29] “Identification of proteins that interact with NF-YA”. FEBS Lett. 460 (1): 41–5. (October 1999). Bibcode: 1999FEBSL.460...41Y. doi:10.1016/s0014-5793(99)01311-3. PMID 10571058.

[pmid10777532-30] “Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor”. J. Biol. Chem. 275 (17): 12470–4. (April 2000). doi:10.1074/jbc.275.17.12470. PMID 10777532.

[pmid9786846-31] “Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations”. J. Biol. Chem. 273 (44): 28564–7. (October 1998). doi:10.1074/jbc.273.44.28564. PMID 9786846.

[pmid11136726-32] “Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1”. J. Biol. Chem. 276 (13): 10413–22. (March 2001). doi:10.1074/jbc.M008625200. PMID 11136726.

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血清応答因子

機能

臨床的意義

相互作用

出典

関連文献

関連項目

外部リンク